•Jaundice appeared due to mainly liver disease because of increased bilirubin level in the blood. jaundice also develops due to drugs vascular and mass lesion. the diagnosis of jaundice made by patients history, physical examination, and laboratory tests. Liver function and structure of jaundice •Liver receives 20% of the blood flow is oxygen-rich blood flow from the hepatic artery, and 80% nutrition-rich blood from portal vein arising from the stomach, intestine, pancreas, and spleen. •Hepatocytes are the major cells in the liver, remaining cells are kuffer cell (reticuloendothelial system ), stellate (fat cell), endothelial and blood vessels cell, bile ductular cell. • Portal area consists of small arteries, bile ducts, and lymphatics organized in the loose connecting stroma of matrix and collagen. Blood flowing into the portal area is distributed through the sinusoids, passing from zone 1 to zone 3 of the acinus and drain into the hepatic vein(central vein)